Most people notice improvement within 2-3 days of starting treatment, though this varies by individual and infection type. For best results, start taking Zoviclovir 200 at the first sign of symptoms (tingling, burning, or itching). Complete healing typically occurs within 7-10 days for most herpes infections. Shingles may take slightly longer to resolve completely, but pain and discomfort should begin improving within the first few days of treatment.