Initial gastrointestinal effects (nausea, diarrhea, stomach upset) occur in about 30% of users but usually improve within 2-3 weeks. Taking with food and starting with low doses significantly reduces these effects. Extended-release formulations cause fewer GI issues.
Can Metformin help with weight loss?
Yes, Metformin often leads to modest weight loss (5-10 pounds on average) or prevents weight gain common with other diabetes medications. It reduces appetite and improves insulin resistance, making it easier to maintain healthy weight.
Is Metformin safe for long-term use?
Metformin has an excellent long-term safety profile with 60+ years of use. Regular monitoring of vitamin B12 levels and kidney function is recommended. It's one of the few diabetes medications shown to potentially reduce cardiovascular complications.
Why do doctors prescribe Metformin first?
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Metformin is the preferred first-line treatment due to its effectiveness, safety profile, low cost, and additional benefits beyond blood sugar control. It doesn't cause hypoglycemia when used alone and may offer cardiovascular protection.
